Date |
Topic |
Lecturer |
|
1 |
Jan 15 |
Ligand binding and linkage |
Di Cera |
2 |
Jan 17 |
Enzyme kinetics and allostery | Di Cera |
3 |
Jan 22 |
Molecular recognition: driving forces and mechanisms |
Di Cera |
4 |
Jan 24 |
Molecular recognition: mutational effects |
Di Cera |
5 |
Jan 29 |
Proteases: activity, specificity, biological roles |
Di Cera |
6 |
Jan 31 |
Maintaining the integrity of the vasculature: the structure of blood vessels and platelets; the organization of the blood coagulation and fibrinolytic systems. Platelet adhesion and two disorders: von Willebrand disease and thrombotic thrombocytopenic purpura |
Sadler |
7 |
Feb 05 |
Making, breaking, and preventing blood clots: initiation and propagation of blood coagulation; fibrin self-assembly; regulation of fibrin degradation; oral anticoagulants |
Sadler |
8 |
Feb 07 |
Hemophilia, biochemistry to bedside: regulation of factor X activation in time and space; medical consequences of factor VIII and factor IX mutations; treatment of hemophilia with recombinant factor VIII, factor IX, or factor VIIa |
Sadler |
9 |
Feb 12 |
Innate immunity: protecting self and processing altered self |
Atkinson |
10 |
Feb 14 |
Human disease resulting from deficient complement activation |
Atkinson |
11 |
Feb 19 |
Human disease resulting from deficient complement regulation |
Atkinson |
12 |
Feb 21 |
Diabetes: ATP-sensitive K+ channels. I. |
Nichols |
13 |
Feb 26 |
Diabetes: ATP-sensitive K+ channels. II. |
Nichols |
14 |
Feb 28 |
Diabetes: ATP-sensitive K+ channels. III. |
Nichols |
Mar 04 |
Reading period - no class |
||
Mar 06 |
MIDTERM EXAM |
|
|
Mar 11 |
Spring Break - No class |
||
Mar 13 |
Spring Break - No class |
||
15 |
Mar 18 |
Diabetes: fatty acids and CD36. I |
Abumrad |
16 |
Mar 20 |
Diabetes: fatty acids and CD36. II |
Abumrad |
17 |
Mar 25 |
Diabetes: fatty acids and CD36. III |
Abumrad |
18 |
Mar 27 |
Alzheimer's disease: overview and pathophysiology |
Goate |
19 |
Apr 01 |
Is Aß central to Alzheimer's disease pathogenesis? |
Goate |
20 |
Apr 03 |
How does APOE modify risk for Alzheimer's disease? |
Fagan |
21 |
Apr 08 |
What is a biomarker and why do we need them? |
Fagan |
22 |
Apr 10 |
Metabolism of CDF proteins, a new tool for drug testing |
Bateman |
23 |
Apr 15 |
The Notch receptor. I. |
Kopan |
24 |
Apr 17 |
The Notch receptor. II. |
Kopan |
25 |
Apr 22 |
Host/pathogen interactions in sepsis |
Marshall |
26 |
Apr 24 |
Therapeutic approaches to sepsis |
Marshall |
27 |
Apr 29 |
Therapeutic approaches to AIDS |
Marshall |
May 05 |
FINAL EXAM |
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