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Peter M. Burgers
Professor
Dept. of Biochemistry and
Molecular Biophysics |
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Mailing Address:
WUSM - Biochemistry Dept.
660 S. Euclid Ave., MS8231
St. Louis, MO 63110
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Research
The Burgers lab studies DNA replication and DNA damage response in eukaryotic cells. Using yeast as a model organism, the lab integrates the biochemical analysis of DNA-protein interactions in purified model systems with the genetic analysis of targeted yeast mutants. Specific areas of interest are lagging strand DNA replication and Okazaki fragment maturation, damage induced mutagenesis, and DNA damage cell cycle checkpoints.
Selected Publications
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Pike, J.E., Burgers, P.M., Campbell, J.L. and Bambara, R.A. Pif1 helicase lengthens some Okazaki fragment flaps necessitating Dna2 nuclease/helicase action in the two-nuclease processing pathway. (E-pub ahead of print.) (2009).
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Navadgi-Patil, V.M. and Burgers, P.M. A tale of two tails: Activation of DNA damage checkpoint kinase Mec1/ATR by the 9-1-1 clamp and by Dpb11/TopBP1. DNA Repair 8:996-1003 (2009).
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Stone, J.E., Kissling, G.E., Lujan, S.A., Rogozin, I.B., Stith, C.M., Burgers, P.M. and Kunkel, T.A. Low-fidelity DNA synthesis by the L979F mutator derivative of Saccharomyces cerevisiae DNA polymerase {zeta}. Nucleic Acids Res.37:3774-3787 (2009).
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McCulloch, S.D., Kokoska, R.J., Garg, P., Burgers, P.M. and Kunkel, T.A. The efficiency and fidelity of 8-oxo-guanine bypass by DNA polymerases {delta} and {eta}. Nucleic Acids Res 37:2830-2840 (2009).
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Chon, H., Vassilev, A., Depamphilis, M.L., Zhao, Y., Zhang, J., Burgers, P.M., Crouch, R.J. and Cerritelli, S.M. Contributions of the two accessory subunits, RNASEH2B and RNASEH2C, to the activity and properties of the human RNase H2 complex. Nucleic Acids Res. 37:96-110 (2009).
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Burgers, P.M. Polymerase dynamics at the eukaryotic DNA replication fork. J Biol Chem 284:4041-4045 (2009).
