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William A. Frazier
Professor
Dept. of Biochemistry and
Molecular Biophysics |
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Mailing Address:
WUSM - Biochemistry Dept.
660 S. Euclid Ave., MS8231
St. Louis, MO 63110
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Research
A Nobel Prize was awarded for the discovery of the physiological role ofnitric oxide and NO was named the 1992 “Molecule of the Year” by Science magazine. The Frazier lab discovered that CD47 is a receptor for thrombospondin-1 and that TSP1 ligation of CD47 negates the beneficial effects of NO signaling thereby exacerbating all cardiovascular diseases. We are now studying the molecular details of the TSP1-CD47 binding interaction, the mechanism of CD47 inhibition of NO signaling and discovering new phenotypes of CD47-null mice.
Selected Publications
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Lawrence, D.W., King, S.B., Frazier, W.A. and Koenig, J.M. Decreased CD47 expression during spontaneous apoptosis targets neutrophils for phagocytosis by monocyte-derived macrophages. Early Human Dev. 85:659-663 (2009).
Isenberg, J.S., Qin, Y., Maxhimer, J.B., Sipes, J.M., Despres, D., Schnermann, J., Frazier, W.A. and Roberts, D.D. Thrombospondin-1 and CD47 regulate blood pressure and cardiac responses to vasoactive stress. Matrix Biology 28:110-119 (2009).
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Uluçkan, O., Becker, S.N., Deng, H., Zou, W., Prior, J.L., Piwnica-Worms, D., Frazier, W.A. and Weilbaecher, K.N. CD47 regulates bone mass and tumor metastasis to bone. Cancer Res 69:3196-3204 (2009).
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Isenberg, J.S. Annis, D.S., Pendrak, M.L., Ptaszynska, M., Frazier, W.A., Mosher, D.F. and Roberts, D.D. Differential interactions of thrombospondins-1, -2 and -4 with CD47 and effects on cGMP signaling and ischemic injury responses. J Biol Chem 284:1116-1125 (2009).
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Kohyama, M., Ise, W., Edelson, B.T., Wilker, P.R., Hildner, K., Mejia, C., Frazier, W.A., Murphy, T.L. and Murphy, K.M. Role for Spi-C in the development of red pulp macrophages and splenic iron homeostasis. Nature 457:318-321 (2009).
