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Garland Marshall
Professor
Dept. of Biochemistry and
Molecular Biophysics |
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Mailing Address:
WUSM - Biochemistry Dept.
660 S. Euclid Ave., MS8231
St. Louis, MO 63110
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Research Interests
Major focus is molecular recognition - the basis of
intermolecular interactions and specificity seen in drug
and hormone receptors, antigen-antibody and
substrate-enzyme systems.
Selected Publications
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Marshall, G.R., Kuster, D.J. and Che, Y. Chemogenomics with protein secondary-structure mimetics. Methods Mol Biol. 575:123-158 (2009).
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Nikiforovich, G.V., Taylor, C.M., Marshall, G.R. and Baranski, T.J. Modeling the possible conformations of the extracellular loops in G-protein-coupled receptors. Proteins (E-pub ahead of print.) (2009).
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Oprea, T.I., Bologa, C.G., Boyer, S., Curpan, R.F., Glen, R.C., Hopkins, A.L., Lipinski, C.A., Marshall, G.R., Martin, Y.C., Ostopovici-Halip, L., Rishton, G., Ursu, O., Vaz, R.J., Waller, C., Waldmann, H. and Sklar, L.A. A Crowdsourcing evaluation of the NIH chemical probes. Nat Chem Biol 5:441-447 (2009).
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Arbor, S. and Marshall, G.R. A virtual library of constrained cyclic tetrapeptides that mimics all four side-chain orientations for over half the reverse turns in the protein data bank. J Comput Aided Mol Des. 23:87-95 (2009).
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Taylor, C.M., Barda, Y., Kisselev, O.G. and Marshall, G.R. Modulating G-protein coupled receptor/G-protein signal transduction by small molecules suggested by virtual screening. J Med Chem 51:5297-5303 (2008).
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Nikiforovich, G.V., Marshall, G.R. and Baranski, T.J. Modeling molecular mechanisms of binding of the anaphylatoxin C5a to the C5a receptor. Biochemistry 47:3117-3130 (2008).
