Peter Burgers
Post-doctoral positions are available to study DNA-protein interactions in eukaryotic DNA replication and DNA damage response mechanisms. Our studies integrate biochemical with genetic analysis using Saccharomyces cerevisiae as a model organism. Applicants should possess a strong background in biochemistry, and have experience in protein purification and analysis. Experience in genetic analysis is preferred. Please, see the lab’s home page for more information.
Interested candidates should send their c.v. and three letters of
reference to:
Dr. Peter Burgers
Professor of Biochemistry and Molecular Biophysics
Washington University School of Medicine
660 S. Euclid Ave., Campus Box 8231
St. Louis, MO 63110
E-mail: burgers@biochem.wustl.edu
Tom Ellenberger
Post-doctoral positions are available to study the molecular structures and cellular functions of proteins involved in DNA damage responses and genomic maintenance. We are using high throughput screening and rational, structure-based design to identify biologically active small molecules as probes of these processes. Applicants should possess a strong background in biochemistry, with experience in protein purification and functional characterization. Experience in x-ray crystallography and/or cell culture is preferred. Interested candidates must be self-motivated with strong communication skills. Please see my lab webpage for more information.
Interested candidates should send their c.v. and three letters of
reference to:
Dr. Tom Ellenberger
Wittcoff Professor and Head
Dept. of Biochemistry and Molecular Biophysics
Washington University School of Medicine
660 S. Euclid Ave., Campus Box 8231
St. Louis, MO 63110
Tel: 314-362-0287
Fax: 314-362-4432
Or send e-mail to tome@biochem.wustl.edu.
Elliot Elson
Gregory Goldberg and Elliot Elson have a postdoctoral position to investigate mechanistic and functional properties of matrix metalloproteinases. In particular we are interested in the dynamic interactions of these enzymes with substrate fibrils in relation to their ability to degrade extracellular matrix molecules and to contribute to cell locomotion and matrix remodeling. Applicants should possess a strong background in cell biology and/or molecular biophysics. Please see the following papers for background of these studies.
- Collier, I. E., S. Saffarian, B. L. Marmer, E. L. Elson and G. Goldberg (2001). "Substrate recognition by gelatinase a: the c-terminal domain facilitates surface diffusion." Biophys J 81(4): 2370-7.
- Saffarian, S., I. E. Collier, B. L. Marmer, E. L. Elson and G. Goldberg (2004). "Interstitial collagenase is a Brownian ratchet driven by proteolysis of collagen." Science 306(5693): 108-11.
- Strongin, A. Y., I. Collier, G. Bannikov, B. L. Marmer, G. A. Grant and G. I. Goldberg (1995). "Mechanism of cell surface activation of 72-kDa type IV collagenase. Isolation of the activated form of the membrane metalloprotease." J Biol Chem 270(10): 5331-8.
Interested candidates should send their c.v. and three letters of
reference to:
Dr. Ellliot Elson
225 McDonnell Science Building
Washington University School of Medicine
Dept. of Biochemistry & Molecular Biophysics
660 S. Euclid Avenue
Campus Box 8231
St. Louis, MO 63110
Tel: 314-362-3346
Fax: 314-362-7183
Or send e-mail to: elson@wustl.edu and/or Goldberg@beckermail.wustl.edu
Eric A. Galburt
A postdoctoral position is available to study the mechanism of Eukaryotic transcription initiation through the application of single molecule assays. The ideal candidate will have a strong physics background and an interest in applying physical methods to complex biochemical systems. Our studies will center on the application of optical and magnetic trapping single molecule techniques with an eye toward developing these techniques to answer specific questions.
For more information about our research, please see the website (http://biochem.wustl.edu/~egalburt/) or email Dr. Galburt (egalburt@biochem.wustl.edu).
Interested candidates should send their c.v. and three letters of reference to:
Dr. Eric Galburt
Assistant Professor of Biochemistry and Molecular Biophysics
Washington University School of Medicine
660 S. Euclid Ave., Campus Box 8231
Saint Louis, Missouri 63110
Katherine Henzler-Wildman
A postdoc position is available to study the mechanism of multidrug resistance transporters. Our studies combine NMR structure and dynamics measurements with traditional biochemical assays to build an atomic-resolution model of the protein throughout the transport cycle. The applicant should have a strong background in biochemistry or biophysics with experience in modern NMR techniques (solution or solid-state) and/or membrane protein expression and purification. Experience with NMR of large systems or transport assays is preferred.
Interested candidates should send their c.v. and three letters of reference to:
Dr. Katie Henzler-Wildman
Washington University School of Medicine
660 S. Euclid Ave., Campus Box 8231
St. Louis, MO 63110
email: khenzler@biochem.wustl.edu